Details

Autor(en) / Beteiligte

• Zhang, Pei
• Shen, Haigen
• Zhu, Lin
• Cao, Weiguo
• Li, Chaozhong

Titel

Radical C(sp2)–H Trifluoromethylation of Aldehydes in Aqueous Solution

Ist Teil von

• Organic letters, 2018-11, Vol.20 (22), p.7062-7065

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The copper-mediated C­(sp2)–H trifluoromethylation of aldehydes is described. The reaction of aldehydes with (bpy)­Cu­(CF3)3, Et3SiH, and K2S2O8 in aqueous acetone at room temperature provides the corresponding trifluoromethyl ketones in satisfactory yields. The protocol is applicable to both aliphatic and aromatic aldehydes and exhibits a broad substrate scope and wide functional group compatibility. A mechanism involving Cu­(II)-mediated trifluoromethylation of acyl radicals is proposed.