Details

Autor(en) / Beteiligte

• Maurinsh, Yuris
• Rosemeyer, Helmut
• Esnouf, Robert
• Medvedovici, Andrei
• Wang, Jing
• Ceulemans, Griet
• Lescrinier, Eveline
• Hendrix, Chris
• Busson, Roger
• Sandra, Pat
• Seela, Frank
• Van Aerschot, Arthur
• Herdewijn, Piet

Titel

Synthesis and Pairing Properties of Oligonucleotides Containing 3-Hydroxy-4-hydroxymethyl-1-cyclohexanyl Nucleosides

Ist Teil von

• Chemistry : a European journal, 1999-07, Vol.5 (7), p.2139-2150

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Wiley Online Library - Journals

Beschreibungen/Notizen

• Cyclohexanyl nucleic acid (CNA) represents a novel enantioselective Watson–Crick base‐pairing system. Homochiral oligomers of equivalent chirality show antiparallel Watson–Crick pairing, while those of opposite sense do not. D‐CNA hybridizes with natural nucleic acids, preferentially with RNA. A conformational change involving chair inversion is expected to occur upon duplex formation (A→B).