Details

Autor(en) / Beteiligte

• Boldrini, L.
• Bartoletti, R.
• Giordano, M.
• Manassero, F.
• Selli, C.
• Panichi, M.
• Galli, L.
• Farci, F.
• Faviana, P.

Titel

C-MYC, HIF-1α, ERG, TKT, and GSTP1: an Axis in Prostate Cancer?

Ist Teil von

• Pathology oncology research, 2019-10, Vol.25 (4), p.1423-1429

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• To analyze putative biomarkers for prostate cancer (PCA) characterization, the second leading cause of cancer-associated mortality in men. Quantification of the expression level of c-myc and HIF-1α was performed in 72 prostate cancer specimens. A cohort of 497 prostate cancer patients from The Cancer Genome Atlas (TCGA) database was further analyzed, in order to test our hypothesis. We found that high c-myc level was significantly associated with HIF-1α elevated expression ( p  = 0.008) in our 72 samples. Statistical analysis of 497 TCGA prostate cancer specimens confirmed the strong association ( p  = 0.0005) of c-myc and HIF-1α expression levels, as we found in our series. Moreover, we found high c-myc levels significantly associated with low Glutatione S-transferase P1 (GSTP1) expression ( p  = 0.01), with high Transketolase (TKT) expression ( p  < 0.0001). High TKT levels were found in TCGA samples with low GSTP1 mRNA (p < 0.0001), as shown for c-myc , and with ERG increased expression ( p  = 0.02). Finally, samples with low GSTP1 expression displayed higher ERG mRNA levels than samples with high GSTP1 score ( p  < 0.0001), as above shown for c-myc . Our study emphasizes the notion of a potential value of HIF-1α and c-myc as putative biomarkers in prostate cancer; moreover TCGA data analysis showed a putative crosstalk between c-myc, HIF-1α, ERG, TKT, and GSTP1, suggesting a potential use of this axis in prostate cancer.