Details

Autor(en) / Beteiligte

• Rajagopalan, Sanjay
• Al-Kindi, Sadeer G
• Brook, Robert D

Titel

Air Pollution and Cardiovascular Disease: JACC State-of-the-Art Review

Ist Teil von

• Journal of the American College of Cardiology, 2018-10, Vol.72 (17), p.2054-2070

Ort / Verlag

United States: Elsevier Limited

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Fine particulate matter <2.5 μm (PM ) air pollution is the most important environmental risk factor contributing to global cardiovascular (CV) mortality and disability. Short-term elevations in PM increase the relative risk of acute CV events by 1% to 3% within a few days. Longer-term exposures over several years increase this risk by a larger magnitude (∼10%), which is partially attributable to the development of cardiometabolic conditions (e.g., hypertension and diabetes mellitus). As such, ambient PM poses a major threat to global public health. In this review, the authors provide an overview of air pollution and health, including assessment of exposure, impact on CV outcomes, mechanistic underpinnings, and impact of air pollution reduction strategies to mitigate CV risk. The review concludes with future challenges, including the inextricable link between air pollution and climate change, and calls for large-scale trials to allow the promulgation of formal evidence-based recommendations to lower air pollution-induced health risks.