Details

Autor(en) / Beteiligte

• Hajek, Milan
• Krsek, Pavel
• Dezortova, Monika
• Marusic, Petr
• Zamecnik, Josef
• Kyncl, Martin
• Tomasek, Martin
• Krijtova, Hana
• Komarek, Vladimir

Titel

super(1)H MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy

Ist Teil von

• European radiology, 2009-02, Vol.19 (2), p.400-408

Erscheinungsjahr

2009

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The aim of the study was to analyze the lateralizing value of proton magnetic resonance spectroscopy ( super(1)H MRS) in histopathologically different subgroups of mesial temporal lobe epilepsies (MTLE) and to correlate results with clinical, MRI and seizure outcome data. A group of 35 patients who underwent resective epilepsy surgery was retrospectively studied. Hippocampal super(1)H MR spectra were evaluated. Metabolite concentrations were obtained using LCModel and NAA/Cr, NAA/Cho, NAA/(Cr+Cho), Cho/Cr ratios and coefficients of asymmetry were calculated. MRI correctly lateralized 89% of subjects and super(1)H MRS 83%. MRI together with super(1)H MRS correctly lateralized 100% of patients. Nineteen subjects had 'classical' hippocampal sclerosis (HS), whereas the remaining 16 patients had 'mild' HS. Nineteen patients had histopathologically proven malformation of cortical development (MCD) in the temporal pole; 16 subjects had only HS. No difference in super(1)H MRS findings was found between patients in different histopathological subgroups of MTLE. Our results support the hypothesis that super(1)H MRS abnormalities do not directly reflect histopathological changes in MTLE patients. Subjects with non-lateralized super(1)H MRS abnormalities did not have a worse postoperative seizure outcome. We found no significant impact of contralateral super(1)H MRS abnormality on post-surgical seizure outcome.