Details

Autor(en) / Beteiligte

• Stoner, Gary D.
• Sardo, Christine
• Apseloff, Glen
• Mullet, Dan
• Wargo, Wayne
• Pound, Vickie
• Singh, Alpana
• Sanders, James
• Aziz, Robeena
• Casto, Bruce
• Sun, XiaoLi

Titel

Pharmacokinetics of Anthocyanins and Ellagic Acid in Healthy Volunteers Fed Freeze-Dried Black Raspberries Daily for 7 Days

Ist Teil von

• Journal of clinical pharmacology, 2005-10, Vol.45 (10), p.1153-1164

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Eleven subjects completed a clinical trial to determine the safety/tolerability of freeze‐dried black raspberries (BRB) and to measure, in plasma and urine, specific anthocyanins‐cyanidin‐3‐glucoside, cyanidin‐3‐sambubioside, cyanidin‐3‐rutinoside, and cyanidin‐3‐xylosylrutinoside, as well as ellagic acid. Subjects were fed 45 g of freeze‐dried BRB daily for 7 days. Blood samples were collected predose on days 1 and 7 and at 10 time points postdose. Urine was collected for 12 hours predose on days 1 and 7 and at three 4‐hour intervals postdose. Maximum concentrations of anthocyanins and ellagic acid in plasma occurred at 1 to 2 hours, and maximum quantities in urine appeared from 0 to 4 hours. Overall, less than 1% of these compounds were absorbed and excreted in urine. None of the pharmacokinetic parameters changed significantly between days 1 and 7. In conclusion, 45 g of freeze‐dried BRB daily are well tolerated and result in quantifiable anthocyanins and ellagic acid in plasma and urine.