Details

Autor(en) / Beteiligte

• Dvorak, Ann M

Titel

Mast Cell-Derived Mediators of Enhanced Microvascular Permeability, Vascular Permeability Factor/ Vascular Endothelial Growth Factor, Histamine, and Serotonin, Cause Leakage of Macromolecules through a New Endothelial Cell Permeability Organelle, the Vesiculo-Vacuolar Organelle

Ist Teil von

• Chemical immunology and allergy, 2005, Vol.85, p.185-204

Ort / Verlag

Basel, Switzerland: S. Karger AG

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Proof of principle for a vesicular transport mechanism for effecting PMD of mast cells and basophils was offered in Chapter 7. We have also proposed that upregulation of this vesicular traffic would result in vesicular fusions, forming channels (sacs) in continuity with the plasma membrane and functionally providing a conduit for granule extrusion. This well-known mode of secretion, when stimulated by IgE mechanisms in basophils and mast cells, is called anaphylactic degranulation (AND). Release of powerful mediators of allergic inflammation occurs with either of these modes of secretion. Mast cells traditionally can be found in perivascular locations and basophils, given appropriate stimuli, rapidly leave the blood vascular space by a transendothelial cell route to enter the perivascular milieu. Mediators released from these cells have powerful permeabilizing properties. We used ultrastructural methods to define the traffic route(s) of macromolecular leakage from the microvasculature exposed to the mediators released from basophils and mast cells in allergic inflammation and from tumor cells in the tumor stroma.