Details

Autor(en) / Beteiligte

• Hemmert, Rachael
• Schliep, Karen C.
• Willis, Sydney
• Peterson, Charles Matthew
• Louis, Germaine Buck
• Allen‐Brady, Kristina
• Simonsen, Sara E.
• Stanford, Joseph B.
• Byun, Jiyoung
• Smith, Ken R.

Titel

Modifiable life style factors and risk for incident endometriosis

Ist Teil von

• Paediatric and perinatal epidemiology, 2019-01, Vol.33 (1), p.19-25

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Caffeine, alcohol, smoking and physical activity are known to alter sex steroid synthesis, which may affect hormone‐dependent gynaecologic disease risk, such as endometriosis; however, few studies have assessed life style factors prior to endometriosis diagnosis. Methods Four hundred and seventy three women, ages 18‐44 years, underwent laparoscopy or laparotomy, regardless of clinical indication, at 14 clinic sites, 2007‐2009. Women with prior surgically confirmed endometriosis were excluded. Life style factors were assessed prior to surgery. Adjusted risk ratios (RR) of endometriosis by caffeine, alcohol, smoking (serum cotinine), and physical activity were estimated, adjusting for age, marital status, education, race/ethnicity, age at menarche, gravidity, BMI, study site, and other life style factors. Results There were no associations between women with endometriosis and alcohol consumption (RR 0.9, 95% CI 0.7, 1.3), caffeine consumption (RR 1.1, 95% CI 0.8, 1.5), or smoking (serum cotinine <10 vs ≥10 ng/mL; RR 1.0, 95% CI 0.7, 1.6). Similar null findings were found between endometriosis and weekly occurrences of physical activity and total walking, moderate, and vigorous activity; a modest trend was found between total daily sitting time and increased endometriosis risk. Conclusions This study, which is unique in its capture of life style exposures prior to incident endometriosis diagnosis, largely found no association between alcohol, caffeine, smoking, and physical activity and risk of endometriosis.