Details

Autor(en) / Beteiligte

• Newman, Erika A.
• Abdessalam, Shahab
• Aldrink, Jennifer H.
• Austin, Mary
• Heaton, Todd E.
• Bruny, Jennifer
• Ehrlich, Peter
• Dasgupta, Roshni
• Baertschiger, Reto M.
• Lautz, Timothy B
• Rhee, Daniel S
• Langham, Max R.
• Malek, Marcus M.
• Meyers, Rebecka L
• Nathan, Jaimie D.
• Weil, Brent R
• Polites, Stephanie
• Madonna, Mary Beth

Titel

Update on neuroblastoma

Ist Teil von

• Journal of pediatric surgery, 2019-03, Vol.54 (3), p.383-389

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Neuroblastoma is an embryonic cancer arising from neural crest stem cells. This cancer is the most common malignancy in infants and the most common extracranial solid tumor in children. The clinical course may be highly variable with the possibility of spontaneous regression in the youngest patients and increased risk of aggressive disease in older children. Clinical heterogeneity is a consequence of the diverse biologic characteristics that determine patient risk and survival. This review will focus on current progress in neuroblastoma staging, risk stratification, and treatment strategies based on advancing knowledge in tumor biology and genetic characterization. Review article. Level II.