Details

Autor(en) / Beteiligte

• Acharya, Shrikrishna V
• Gopal, Raju A
• George, Joe
• Bandgar, Tushar R
• Menon, Padma S
• Shah, Nalini S

Titel

Utility of single luteinizing hormone determination 3h after depot leuprolide in monitoring therapy of gonadotropin-dependent precocious puberty

Ist Teil von

• Pituitary, 2009-12, Vol.12 (4), p.335-338

Erscheinungsjahr

2009

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To determine utility of luteinizing hormone (LH) estimation, post intramuscular (IM) depot leuprolide in comparison with subcutaneous leuprolide stimulation test. Test for monitoring therapy in patients with gonadotropin dependent precocious puberty (GDPP). In seven patients of GDPP, who were treated with 11.25mg depot leuprolide, the LH peak after subcutaneous (sc) test was compared with LH at hourly interval for 4h after IM depot leuprolide for 13 tests and 3rd hour value for next ten tests. These two values were compared both before and after therapy. Before therapy, the mean plus or minus SD LH peak after subcutaneous leuprolide stimulation test was 20.6 plus or minus 7.85IU/l (range 9.64-30.4IU/l), and it was 27.3 plus or minus 12.21IU/l 3h after the first depot leuprolide injection (range 10.5-45.4IU/l). During therapy, the mean plus or minus SD of LH peak after sc stimulation test was 1.96 plus or minus 0.75IU/l (range 1.1-3.1IU/l), and it was 2.58 plus or minus 0.54IU/l (range 1.4-3.4IU/l) 3h after depot leuprolide injection. Three-hour LH value following IM depot leuprolide injection (11.25mg) can be used for monitoring therapy in patients with GDPP because of its convenience and cost effectiveness.