Details

Autor(en) / Beteiligte

• Campanile, F.
• Bongiorno, D.
• Mongelli, G.
• Zanghì, G.
• Stefani, S.

Titel

Bactericidal activity of ceftobiprole combined with different antibiotics against selected Gram-positive isolates

Ist Teil von

• Diagnostic microbiology and infectious disease, 2019-01, Vol.93 (1), p.77-81

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• This study investigated the in vitro susceptibility of ceftobiprole and its potential synergistic activity in combination with other antimicrobials against 46 selected Gram-positive pathogens displaying resistance or decrease susceptibility to several drugs. The gradient-cross method was used to assess synergism between ceftobiprole and daptomycin, levofloxacin, linezolid, rifampicin and piperacillin/tazobactam. Time-kill curves were performed for seven representative isolates. Ceftobiprole MICs ranged from 0.25–6 mg/L for staphylococci; 4–≥32 mg/L for Enterococcus faecalis, and 0.38–≥32 mg/L for E. faecium. Ceftobiprole plus daptomycin was synergistic against all isolates. Ceftobiprole plus linezolid was synergistic against 4 isolates belonging to different species. Ceftobiprole plus levofloxacin was synergistic only against enterococci. In conclusion, ceftobiprole exhibited a potent in vitro antibacterial activity and exhibited synergy with daptomycin against all Gram-positive isolates, despite their antibiotic resistance phenotypes. The use of ceftobiprole in combination may provide a promising alternative therapy for the treatment of resistant Gram-positive infections. •High in-vitro activity of ceftobiprole against Gram-positive isolates.•Synergistic activity was observed with daptomycin against all resistance phenotypes.•Promising alternative drug for the treatment of resistant Gram-positive strains.