Movement disorders, 2004-11, Vol.19 (11), p.1279-1284
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting "sleep attacks"
- Ist Teil von
- Movement disorders, 2004-11, Vol.19 (11), p.1279-1284
- Ort / Verlag
- Hoboken: Wiley Subscription Services, Inc., A Wiley Company
- Erscheinungsjahr
- 2004
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0885-3185eISSN: 1531-8257DOI: 10.1002/mds.20245Titel-ID: cdi_proquest_miscellaneous_21143267
- Format
- –
- Schlagworte
- Aged, Alleles, Antiparkinson Agents - adverse effects, Antiparkinson Agents - therapeutic use, Biological and medical sciences, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Disorders of Excessive Somnolence - chemically induced, Disorders of Excessive Somnolence - genetics, Dopamine Agonists - adverse effects, Dopamine Agonists - therapeutic use, dopamine receptor, Female, Gene Frequency - genetics, Genetic Predisposition to Disease - genetics, Genotype, Humans, Male, Medical sciences, Middle Aged, Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis, Narcolepsy - chemically induced, Narcolepsy - genetics, Neurology, Parkinson Disease - drug therapy, Parkinson Disease - genetics, Parkinson's disease, Pilot Projects, polymorphism, Polymorphism, Genetic - drug effects, Polymorphism, Genetic - genetics, Receptors, Dopamine - drug effects, Receptors, Dopamine - genetics, Receptors, Dopamine D2 - drug effects, Receptors, Dopamine D2 - genetics, Receptors, Dopamine D3, Receptors, Dopamine D4, Risk Factors, sudden onset of sleep (SOS)