Details

Autor(en) / Beteiligte

• Argudo, Pablo G.
• Carril, Mónica
• Martín‐Romero, María T.
• Giner‐Casares, Juan J.
• Carrillo‐Carrión, Carolina

Titel

Surface‐Active Fluorinated Quantum Dots for Enhanced Cellular Uptake

Ist Teil von

• Chemistry : a European journal, 2019-01, Vol.25 (1), p.195-199

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Fluorescent nanoparticles, such as quantum dots, hold great potential for biomedical applications, mainly sensing and bioimaging. However, the inefficient cell uptake of some nanoparticles hampers their application in clinical practice. Here, the effect of the modification of the quantum dot surface with fluorinated ligands to increase their surface activity and, thus, enhance their cellular uptake was explored. Fluorination of nanoparticles (NPs) is presented as a strategy to promote the interactions between NPs and the cell membrane, resulting in efficient cellular uptake of NPs. The increased surface activity of fluorinated NPs, which is demonstrated by using Langmuir monolayers as cell membrane models, seems to be the key feature for their enhanced cellular uptake.