Details

Autor(en) / Beteiligte

• Jia, Yimin
• Chen, Long
• Zhang, Huaibin
• Zheng, Ying
• Jiang, Zhong-Xing
• Yang, Zhigang

Titel

Electrophilic chloro(ω-alkoxy)lation of alkenes employing 1-chloro-1,2-benziodoxol-3-one: facile synthesis of β-chloroethers

Ist Teil von

• Organic & biomolecular chemistry, 2018-10, Vol.16 (39), p.7203-7213

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A four-component reaction for electrophilic chloro(ω-alkoxy)lation of alkenes has been described. The stable chloro-iodine(iii) reagent and SOCl2 were used as electrophilic and nucleophilic chlorine sources, respectively. This approach provides a straightforward way to synthesize various useful β-chloro ω-chloroalkyl ethers from a wide range of alkenes, including electron-deficient, aromatic and unactivated alkenes. The synthetic applications of this approach were also explored in some useful transformations.