Details

Autor(en) / Beteiligte

• Nelson, Taylor A. F.
• Blakey, Simon B.

Titel

Intermolecular Allylic C−H Etherification of Internal Olefins

Ist Teil von

• Angewandte Chemie (International ed.), 2018-11, Vol.57 (45), p.14911-14915

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Herein we report on the development of an oxidative allylic C−H etherification reaction, utilizing internal olefins and alcohols as simple precursors. Key advances include the use of RhCp* complexes to promote the allylic C−H functionalization of internal olefins and the compatibility of the oxidative conditions with oxidatively sensitive alcohols, enabling the direct etherification reaction. Preliminary mechanistic studies, consistent with C−H functionalization as the rate determining step, are presented. Another piece of the π‐allyl puzzle: Rhodium Cp* complexes promote the activation of a broad range of allylic C−H bonds, and catalyze oxidative coupling with complex alcohols, overcoming competing alcohol oxidation reactions to provide direct access to allylic ethers.