Details

Autor(en) / Beteiligte

• Simonetti, Boris
• Cullen, Peter J

Titel

Actin-dependent endosomal receptor recycling

Ist Teil von

• Current opinion in cell biology, 2019-02, Vol.56, p.22-33

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •Actin polymerization on endosomes is primarily controlled by the regulation of the WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and associated cargo-selective machineries to facilitate the process of cargo retrieval and recycling.•Branched actin networks support the formation and stabilization of endosomal tubular domains where cargoes are segregated and recycled.•Actin polymerization and actin-based motors facilitate the transport of cargo-enriched post endosomal carriers. Endosomes constitute major sorting compartments within the cell. There, a myriad of transmembrane proteins (cargoes) are delivered to the lysosome for degradation or retrieved from this fate and recycled through tubulo-vesicular transport carriers to different cellular destinations. Retrieval and recycling are orchestrated by multi-protein assemblies that include retromer and retriever, sorting nexins, and the Arp2/3 activating WASH complex. Fine-tuned control of actin polymerization on endosomes is fundamental for the retrieval and recycling of cargoes. Recent advances in the field have highlighted several roles that actin plays in this process including the binding to cargoes, stabilization of endosomal subdomains, generation of the remodeling forces required for the biogenesis of cargo-enriched transport carriers and short-range motility of the transport carriers.