Details

Autor(en) / Beteiligte

• Dosa, Peter I
• Strah-Pleynet, Sonja
• Jayakumar, Honnappa
• Casper, Martin
• Decaire, Marc
• Xiong, Yifeng
• Lehmann, Juerg
• Choi, Karoline
• Elwell, Katie
• Wong, Amy
• Webb, Robert R
• Adams, John W
• Ramirez, Juan
• Richman, Jeremy G
• Thomsen, William
• Semple, Graeme
• Teegarden, Bradley R

Titel

Solubilized phenyl-pyrazole ureas as potent, selective 5-HT sub(2A) inverse-agonists and their application as antiplatelet agents

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5486-5489

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Potent 5-HT sub(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation.