Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5590-5593
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5590-5593
- Ort / Verlag
- Amsterdam: Elsevier
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A simple and expedient method for the synthesis of a series of 14-aryl-14H-dibenzo[a.j]xanthenes is described through a one-pot condensation of beta-naphthol with aryl aldehydes catalysed by TaCl5 under solvent-free conventional heating. The major advantages of the present method are: high yields, less reaction time, solvent-free condition and easy purification of the products. The synthesized 14-aryl-14H-dibenzo[a.j]xanthenes were evaluated against a panel of six human cancer lines of different tissues. Synthesized compound 3o showed IC50 of 37.9 and 41.3 microM against Colo-205 and 502713, respectively, whereas 3g showed IC50 of 41.9 microM against Colo-205.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2009.08.033Titel-ID: cdi_proquest_miscellaneous_21092139
- Format
- –
- Schlagworte
- Aldehydes - chemistry, Antineoplastic agents, Biological and medical sciences, Catalysis, Cell Line, Tumor, Chlorides - chemistry, Cytotoxins - chemical synthesis, Cytotoxins - chemistry, Cytotoxins - toxicity, Drug Screening Assays, Antitumor, General aspects, Humans, Medical sciences, Naphthols - chemistry, Pharmacology. Drug treatments, Tantalum - chemistry, Xanthenes - chemical synthesis, Xanthenes - chemistry, Xanthenes - toxicity