Details

Autor(en) / Beteiligte

• Hiraki, Akio
• Matsuo, Keitaro
• Wakai, Kenji
• Suzuki, Takeshi
• Hasegawa, Yasuhisa
• Tajima, Kazuo

Titel

Gene–gene and gene–environment interactions between alcohol drinking habit and polymorphisms in alcohol‐metabolizing enzyme genes and the risk of head and neck cancer in Japan

Ist Teil von

• Cancer science, 2007-07, Vol.98 (7), p.1087-1091

Ort / Verlag

Melbourne, Australia: Blackwell Publishing Asia

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Alcohol consumption is a strong risk factor for squamous cell carcinoma of the head and neck (SCCHN). The genetic polymorphisms aldehyde dehydrogenase2 (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in the Japanese population. To clarify the significance of these polymorphisms in SCCHN carcinogenesis, we conducted a matched case‐control study with 239 incident SCCHN subjects and 716 non‐cancer controls. Both ADH2 Arg/Arg and ALDH2 Glu/Lys were found to be independently associated with increased risk, with odds ratios (OR) of 2.67 (95% confidence interval [CI] 1.51–4.57) and 1.66 (95% CI 1.20–2.31), respectively. Further, compared with subjects having both ADH2 His/His and ALDH2 Glu/Glu, the adjusted OR and its 95% CI for those with both ADH2 Arg/Arg and ALDH2 Glu/Lys was 5.00 (2.32–10.71) in all subjects. This combination effect was evident in heavy drinkers (OR 11.3, 95% CI 2.97–43.3) but not in moderate or non‐drinkers. Statistically significant gene–environment interactions between the two polymorphisms and drinking level were seen (ADH2 P = 0.035, ALDH2, P = 0.013). Furthermore, we also found a statistically significant gene–gene interaction between the two polymorphisms (P = 0.042). In conclusion, this case‐control study showed a significantly increased risk of SCCHN in subjects with the ADH2 Arg/Arg and ALDH2 Glu/Lys polymorphisms in a Japanese population. In addition, our results also demonstrated that this risk was associated with significant gene–gene interactions between ADH2 and ALDH2 polymorphisms, as well as gene–environment interactions between these polymorphisms and alcohol drinking. (Cancer Sci 2007; 98: 1087–1091)