Details

Autor(en) / Beteiligte

• Shi, Zhe
• Chen, Ying
• Lu, Cong
• Dong, Li-ming
• Lv, Jing-wei
• Tuo, Qin-hui
• Qin, Li
• Cheng, Shao-wu
• Bu, Lan-lan
• Lin, Na
• Zhu, Xiao-xin
• Liao, Duan-fang
• Liu, Xin-min

Titel

Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin

Ist Teil von

• Pharmacological research, 2018-10, Vol.136, p.172-180

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (via regulating inflammatory process in the CNS, exerting anti-oxidative stress and neuroprotective effect, and preventing Aβ accumulation) and indirect (via maintaining BBB integrity, suppressing systemic inflammation and alleviating intestinal inflammtion) manner. However, the precise mechanism of their anti-neuroinflammatory effects and potential neurotoxicity, which hindered further progress in these aspects, remains unclear. We suggest that further understanding of the PK/PD properties and structure-action relationship of atemisinin and its derivatives will facilitate the development of new therapeutics with better curative effects and safety.