Details

Autor(en) / Beteiligte

• Galli, Jonathan R.
• Austin, Sharon D.
• Greenlee, John E.
• Clardy, Stacey L.

Titel

Stiff person syndrome with Anti‐GAD65 antibodies within the national veterans affairs health administration

Ist Teil von

• Muscle & nerve, 2018-12, Vol.58 (6), p.801-804

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• ABSTRACT Introduction: Stiff person syndrome (SPS) is a neurological disorder characterized by muscle rigidity primarily in the truncal muscles, commonly associated with autoantibodies to the glutamic acid‐decarboxylase 65 kD receptor (GAD65). There is limited epidemiological information on patients with SPS. Methods: We performed a retrospective case review using the National United States Veterans Affairs Health Administration electronic medical record system. We analyzed prevalence, demographics, disease characteristics, and treatment outcomes in SPS patients who were anti‐GAD65 antibody positive. Results: Fifteen patients met our criteria. Point prevalence was 2.06 per million, and period prevalence was 2.71 per million. Men to women ratio was 14:1. All patients benefitted from treatment with symptomatic antispasmodic agents. Ten of 15 patients received intravenous immunoglobulin, with a majority demonstrating stable or improved modified Rankin scores. Discussion: This investigation was a large North American epidemiological study of SPS with predominantly male patients. Symptomatic therapy was beneficial for most patients, with less clear sustained benefit of immunotherapy. Muscle Nerve 58:801–804, 2018