Details

Autor(en) / Beteiligte

• Liu, Yushuang
• Chen, Guangying
• Chen, Xiaoyu
• Chen, Shi-Xin
• Gan, Li-She
• Yuan, Tao

Titel

Colocynthenins A–D, Ring‑A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis

Ist Teil von

• Journal of natural products (Washington, D.C.), 2018-09, Vol.81 (9), p.2115-2119

Ort / Verlag

United States: American Chemical Society and American Society of Pharmacognosy

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Four ring-A seco-cucurbitane triterpenoids, colocynthenins A–D (1–4), together with seven known cucurbitane triterpenoids (5–11), were isolated from the fruits of Citrullus colocynthis. Their structures and absolute configurations were elucidated based on spectroscopic analysis and quantum chemical ECD calculations. Compound 1 possesses an unprecedented 2,11-lactone moiety, while compound 2 is the first reported cucurbitane triterpenoid with an unusual cyano group. Compounds 1 and 3 showed acetylcholinesterase inhibitory activities in a standard in vitro assay, with IC50 values of 2.6 and 3.1 μM, respectively.