Details

Autor(en) / Beteiligte

• Fenoglio, Chiara
• Oldoni, Emanuela
• Serpente, Maria
• De Riz, Milena A.
• Arcaro, Marina
• D'Anca, Marianna
• Pietroboni, Anna M.
• Calvi, Alberto
• Lecchi, Elisabetta
• Goris, An
• Mallants, Klara
• Dubois, Bénédicte
• Comi, Cristoforo
• Cantello, Roberto
• Scarpini, Elio
• Galimberti, Daniela

Titel

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Ist Teil von

• Journal of neuroimmunology, 2018-11, Vol.324, p.129-135

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤ .05 and p ≤ .0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression. [Display omitted] •Long non coding RNAs (lncRNAs) have recently found to be dysregulated in MS patients.•LncRNA PCR arrays were used to screen lncRNA expression levels in PBMC from MS patients.•Several lncRNAs were significantly downregulated in MS patients.•NRON and TUG1 downregulations were then confirmed in the Belgian population.•LncRNAs profiling could represent a new challenge in the research of easy detectable biomarkers of disease.