Details

Autor(en) / Beteiligte

• Borchsenius, Sergey N.
• Daks, Alexandra
• Fedorova, Olga
• Chernova, Olga
• Barlev, Nickolai A.

Titel

Effects of mycoplasma infection on the host organism response via p53/NF‐κB signaling

Ist Teil von

• Journal of cellular physiology, 2019-01, Vol.234 (1), p.171-180

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Mycoplasmas are bacteria lacking the cell wall, which is the major characteristic of this taxonomic class (Mollicutes). Among bacteria, mycoplasmas possess the smallest genome known for free‐living organisms. This feature limits the autonomy of bacteria and makes them increasingly susceptible to changes in the host organism. Many mycoplasmas themselves cause pathological changes in the host organism, often complicated by immune disorders. Infection with certain strains of mycoplasma results in the activation of the nuclear factor kappa‐light‐chain‐enhancer of activated B cells, which is the major mediator of the inflammatory response. Furthermore, mycoplasmas can inhibit p53‐mediated checkpoint control of cell cycle and apoptosis. Collectively, these properties indicate that mycoplasmas might act as cancer‐promoting factors. In this review, we summarize the information known to date on the role of mycoplasmas in the regulation of the host immune response and their functional interactions with p53. The problem of bacterial infection and host response is topical in the area of modern molecular medicine. We review the most common signaling mechanisms that take place in host cells in response to mycoplasma infection, including the p53 response, inflammation caused by nuclear factor kappa‐light‐chain‐enhancer of activated B cells activation, and cross‐talk between these two factors.