Details

Autor(en) / Beteiligte

• Christensen, Martin Roest
• Poulsen, Henrik Enghusen
• Henriksen, Trine
• Weimann, Allan
• Ellervik, Christina
• Lynnerup, Niels
• Rungby, Jørgen
• Banner, Jytte

Titel

Elevated levels of 8-oxoGuo and 8-oxodG in individuals with severe mental illness – An autopsy-based study

Ist Teil von

• Free radical biology & medicine, 2018-10, Vol.126, p.372-378

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Elevated systemic oxidative stress levels of 8-oxoGuo and 8-oxodG have been reported in individuals with severe mental illness (SMI). As no previous studies have addressed the link between local levels of 8-oxoGuo and 8-oxodG in the central nervous system (CNS), measured in cerebrospinal fluid (CSF), and urinary systemic levels, we employed autopsy-based material to elucidate this aspect. Additionally, we investigated the impact of 8-oxoGuo and 8-oxodG levels on the prevalence of somatic co-morbidities. Based on post mortem samples from deceased individuals with SMI (N = 107), we found significantly elevated urinary levels of both 8-oxoGuo and 8-oxodG compared to mentally healthy living controls. While we found an association between urinary and CSF 8-oxodG levels (r = 0.50, P < 0.001), a similar correlation was not evident for 8-oxoGuo (r = 0.15, P = 0.16). Additionally, the two r-values were significantly different (P < 0.001). Neither marker in urine or CSF was associated with obesity-related variables, metabolic syndrome or type 2 diabetes. The post mortem interval did not affect the results, but the agonal phase seemingly introduced bias. This study provided novel insights into the cellular oxidative stress levels in individuals with SMI. We demonstrated that increased oxidative stress locally and systemically is correlated and is a clear phenomenon in SMI. Although post mortem measurements contain some weaknesses, our study indicates DNA as the main site of oxidative stress modifications in the CNS in SMI. This may provide novel opportunities for treatment modalities. Additionally, our study demonstrated the applicability of post mortem material investigating systemic and local 8-oxoGuo and 8-oxodG levels. [Display omitted] •Mentally ill have elevated markers of oxidative stress compared to mentally healthy.•8-oxodG levels in cerebrospinal fluid correlates with ditto levels in urine.•DNA may be the main target for oxidative stress damage in the brain in mental illness.•8-oxoGuo and 8-oxodG appear stable post mortem in urine and cerebrospinal fluid.•Agonal phase might increase levels of oxidative stress.