Details

Autor(en) / Beteiligte

• Doi, Takahiro
• Takahashi, Kazunaga
• Yamazaki, Midori
• Asada, Akiko
• Takeda, Akihiro
• Kiyota, Kyohei
• Tagami, Takaomi
• Sawabe, Yoshiyuki
• Yamano, Tetsuo

Titel

Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement

Ist Teil von

• Journal of pharmaceutical and biomedical analysis, 2018-11, Vol.161, p.61-65

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] •A novel sildenafil analog found from a dietary supplement was investigated by UV spectroscopy and high-resolution MS analysis.•We synthesized propoxyphenyl noracetildenafil as the reference standard.•The illicit sildenafil analogs were mainly detected from the shell of the capsule sample. A new sildenafil analog has been identified in the softgel shell of a dietary supplement. The compound was investigated by UV spectroscopy and high-resolution MS analysis, leading to the proposed structure 1-methyl-5-{5-[2-(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one. A synthetic reference compound with the proposed structure was prepared, and the two sets of analytical data were compared, confirming the structure of the new compound. The compound was named propoxyphenyl noracetildenafil from its structure and similarity with the known compound.