Chemical and Pharmaceutical Bulletin, 2018/11/01, Vol.66(11), pp.1023-1026
2018
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 2018/11/01, Vol.66(11), pp.1023-1026
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Seven anthraquinones including two new compounds namely capillasterquinones A and B (1 and 2) and one new butenolide namely capillasterolide (8) were isolated and structurally elucidated from the crinoid Capillaster multiradiatus. The inhibitory effect of compounds 1–8 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production as well as inhibition of 1 on expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) proteins in RAW264.7 cells were also evaluated. As the obtained results, capillasterquinone A (1) showed strong NO production inhibitory activity with an IC50 of 5.89±0.11 µM. In addition, compound 1 reduced the LPS-induced iNOS and COX-2 expressions in a dose-dependent manner.
- Sprache
- Englisch; Japanisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.c18-00472Titel-ID: cdi_proquest_miscellaneous_2092543969
- Format
- –
- Schlagworte
- 4-Butyrolactone - analogs & derivatives, 4-Butyrolactone - chemistry, 4-Butyrolactone - isolation & purification, 4-Butyrolactone - pharmacology, Animals, Anthraquinone, Anthraquinones, Anthraquinones - chemistry, Anthraquinones - isolation & purification, Anthraquinones - pharmacology, Capillaster multiradiatus, crinoid, cyclooxygenase 2 (COX-2), Cyclooxygenase 2 - metabolism, Cyclooxygenase-2, Dose-Response Relationship, Drug, Echinodermata - chemistry, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - isolation & purification, Enzyme Inhibitors - pharmacology, inducible nitric oxide synthase (iNOS), Lipopolysaccharides, Lipopolysaccharides - antagonists & inhibitors, Lipopolysaccharides - pharmacology, Mice, Molecular Structure, Nitric oxide, nitric oxide (NO) production, Nitric Oxide - antagonists & inhibitors, Nitric Oxide - metabolism, Nitric Oxide Synthase Type II - antagonists & inhibitors, Nitric Oxide Synthase Type II - metabolism, Nitric-oxide synthase, RAW 264.7 Cells, Structure-Activity Relationship