Details

Autor(en) / Beteiligte

• Masala, Alessandra
• Sanna, Simona
• Esposito, Sonia
• Rassu, Mauro
• Galioto, Manuela
• Zinellu, Angelo
• Carru, Ciriaco
• Carrì, Maria Teresa
• Iaccarino, Ciro
• Crosio, Claudia

Titel

Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes

Ist Teil von

• Neuroscience, 2018-10, Vol.390, p.1-11

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• •ALS-causative genes, sod1, tardbp and fus contribute to global epigenome alteration.•Pathological mutant SOD1 (G93A or H80R) induce alterations in histone post-translational modifications and DNA methylation.•The epigenetic effects of TDP43 or FUS are related to specific pathological variants. Neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS), have been associated to alterations in chromatin structure resulting in long-lasting changes in gene expression. ALS is predominantly a sporadic disease and environmental triggers may be involved in its onset. In this respect, alterations in the epigenome can provide the key to transform the genetic information into phenotype. In this paper, we demonstrate that two modifications associated with transcriptional activation, namely dimethylation of lysine 4 on H3 tail (H3K4me2) and phospho-acetylation of serine 10 and lysine 14 on H3 tail (H3K14ac-S10ph), and two modifications associated to transcriptional repression, namely trimethylation of lysine 9 on H3 tail (H3K9me3) and DNA methylation are selectively altered in cellular and animal model of ALS. These results reinforce the idea that epigenetic therapy may represent a potential and attractive approach for ALS treatment.