Details

Autor(en) / Beteiligte

• Norkowski, Stefanie
• Schmidt, M. Alexander
• Rüter, Christian

Titel

The species‐spanning family of LPX‐motif harbouring effector proteins

Ist Teil von

• Cellular microbiology, 2018-11, Vol.20 (11), p.e12945-n/a

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The delivery of effector proteins into infected eukaryotic cells represents a key virulence feature of many microbial pathogens in order to derail essential cellular processes and effectively counter the host defence system. Although bacterial effectors are truly numerous and exhibit a wide range of biochemical activities, commonalities in terms of protein structure and function shared by many bacterial pathogens exist. Recent progress has shed light on a species‐spanning family of bacterial effectors containing an LPX repeat motif as a subtype of the leucine‐rich repeat superfamily, partially combined with a novel E3 ubiquitin ligase domain. This review highlights the immunomodulatory effects of LPX effector proteins, with particular emphasis on the exploitation of the host ubiquitin system.