Details

Autor(en) / Beteiligte

• Geisler, Caroline
• Robbe, David
• Zugaro, Michaël
• Sirota, Anton
• Buzsáki, György

Titel

Hippocampal place cell assemblies are speed-controlled oscillators

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (19), p.8149-8154

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The phase of spikes of hippocampal pyramidal cells relative to the local field {theta} oscillation shifts forward ("phase precession") over a full {theta} cycle as the animal crosses the cell's receptive field ("place field"). The linear relationship between the phase of the spikes and the travel distance within the place field is independent of the animal's running speed. This invariance of the phase-distance relationship is likely to be important for coordinated activity of hippocampal cells and space coding, yet the mechanism responsible for it is not known. Here we show that at faster running speeds place cells are active for fewer {theta} cycles but oscillate at a higher frequency and emit more spikes per cycle. As a result, the phase shift of spikes from cycle to cycle (i.e., temporal precession slope) is faster, yet spatial-phase precession stays unchanged. Interneurons can also show transient-phase precession and contribute to the formation of coherently precessing assemblies. We hypothesize that the speed-correlated acceleration of place cell assembly oscillation is responsible for the phase-distance invariance of hippocampal place cells.