Details

Autor(en) / Beteiligte

• Guo, Jihua
• Jia, Rong

Titel

Splicing factor poly(rC)‐binding protein 1 is a novel and distinctive tumor suppressor

Ist Teil von

• Journal of cellular physiology, 2019-01, Vol.234 (1), p.33-41

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A lot of evidence has been found on the link between tumorigenesis and the aberrant expression of splicing factors. A number of splicing factors have been reported to be either oncogenic or overexpressed in cancer cells. However, splicing factors can also play negative roles in tumorigenesis. In the current review, we focus on splicing factor poly(rC)‐binding protein 1 (PCBP1), a novel tumor suppressor that is characterized by downregulation in many cancer types and shows inhibition of tumor formation and metastasis. Notably, the messenger RNA levels of PCBP1 are not significantly decreased in most cancer types. In fact, PCBP1 protein is often degraded or shows a loss‐of‐function through phosphorylation in cancer cells. PCBP1 is highly homologous to its family member, PCBP2. Interestingly, PCBP2 appears to be an oncogenic splicing factor. A growing body of evidence has shown that PCBP1 regulates alternative splicing, translation, and RNA stability of many cancer‐related genes. Taking together, PCBP1 has distinctive tumor suppressive functions, and increasing PCBP1 expression may represent a new approach for cancer treatment. Poly(rC)‐binding protein 1 (PCBP1) is a novel tumor suppressor. PCBP1 protein is often degraded or shows loss‐of‐function through phosphorylation in cancer cells. PCBP1 regulates alternative splicing, translation, and RNA stability of many cancer‐related genes.