Details

Autor(en) / Beteiligte

• Liu, Jing
• Ma, Rui
• Liu, Yan-Rong
• Xu, Lan-Ping
• Zhang, Xiao-Hui
• Chen, Huan
• Chen, Yu-Hong
• Wang, Feng-Rong
• Han, Wei
• Sun, Yu-Qian
• Yan, Chen-Hua
• Tang, Fei-Fei
• Mo, Xiao-Dong
• Liu, Kai-Yan
• Fan, Qiao-Zhen
• Huang, Xiao-Jun
• Chang, Ying-Jun

Titel

The significance of peri-transplantation minimal residual disease assessed by multiparameter flow cytometry on outcomes for adult AML patients receiving haploidentical allografts

Ist Teil von

• Bone marrow transplantation (Basingstoke), 2019-04, Vol.54 (4), p.567-577

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Nexis

Beschreibungen/Notizen

• A retrospective study (n = 460) was performed to assess the relationship between minimal residual disease (MRD) and transplant outcomes in a haplo-stem cell transplantation (SCT) setting. Patients from the pre-MRDneg group and the pre-MRDpos group had comparable outcomes. Compared to post-MRDneg patients, post-MRDpos patients had a higher incidence of relapse (100.0% vs. 8.3%, p < 0.001), lower incidences of overall survival (OS) (16.9% vs. 78.2%, p < 0.001) and leukemia-free survival (LFS) (0% vs. 76.5%, p < 0.001), and comparable probability of NRM (13.4% vs. 16.9%, p = 0.560). In a second set of analyses, all adult AML patients undergoing haplo-SCT were classified into the MRD /MRD group, the MRD decreasing group, and the MRD increasing group according to MRD dynamics by flow cytometry peri-SCT. Compared to the other two groups, patients from the MRD increasing group had higher cumulative incidences of relapse (MRD increasing, 100.0%; MRD /MRD , 9.6%; MRD decreasing, 19.2%; p < 0.001) and worse probabilities of OS (MRD increasing, 28.5%; MRD /MRD , 76.3%; MRD decreasing, 76.0%; p < 0.001) and LFS (MRD increasing, 0.0%; MRD /MRD , 73.9%; MRD decreasing, 74.0%; p < 0.001). The results indicated that haploidentical allografts might have a beneficial anti-leukemia effect in eradicating pretransplantation MRD, and MRD assessment peri-SCT is useful for risk stratification from a practical perspective.