Details

Autor(en) / Beteiligte

• Datz, Stefan
• Illes, Bernhard
• Gößl, Dorothée
• Schirnding, Constantin V
• Engelke, Hanna
• Bein, Thomas

Titel

Biocompatible crosslinked β-cyclodextrin nanoparticles as multifunctional carriers for cellular delivery

Ist Teil von

• Nanoscale, 2018-08, Vol.10 (34), p.16284-16292

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Nanoparticle-based biomedicine has received enormous attention for theranostic applications, as these systems are expected to overcome several drawbacks of conventional therapy. Herein, effective and controlled drug delivery systems with on-demand release abilities and biocompatible properties are used as a versatile and powerful class of nanocarriers. We report the synthesis of a novel biocompatible and multifunctional material, entirely consisting of covalently crosslinked organic molecules. Specifically, β-cyclodextrin (CD) precursors were crosslinked with rigid organic linker molecules to obtain small (∼150 nm), thermally stable and highly water-dispersible nanoparticles with an accessible pore system containing β-CD rings. The nanoparticles can be covalently labeled with dye molecules to allow effective tracking in in vitro cell experiments. Rapid sugar-mediated cell-uptake kinetics were observed with HeLa cells, revealing exceptional particle uptake within only 30 minutes. Additionally, the particles could be loaded with different cargo molecules showing pH-responsive release behavior. Successful nuclei staining with Hoechst 33342 dye and effective cell killing with doxorubicin cargo molecules were demonstrated in live-cell experiments, respectively. This novel nanocarrier concept provides a promising platform for the development of controllable and highly biocompatible theranostic systems.