Details

Autor(en) / Beteiligte

• Fabiani, Claudia
• Vitale, Antonio
• Rigante, Donato
• Emmi, Giacomo
• Bitossi, Alice
• Lopalco, Giuseppe
• Sota, Jurgen
• Guerriero, Silvana
• Orlando, Ida
• Gentileschi, Stefano
• Iannone, Florenzo
• Frediani, Bruno
• Galeazzi, Mauro
• Vannozzi, Lorenzo
• Tosi, Gian Marco
• Cantarini, Luca

Titel

Comparative efficacy between adalimumab and infliximab in the treatment of non-infectious intermediate uveitis, posterior uveitis, and panuveitis: a retrospective observational study of 107 patients

Ist Teil von

• Clinical rheumatology, 2019-02, Vol.38 (2), p.407-415

Ort / Verlag

London: Springer London

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To compare the efficacy of adalimumab (ADA) and infliximab (IFX) in patients with non-infectious intermediate uveitis, posterior uveitis, and panuveitis. Demographic, clinical, instrumental, and therapeutic data from patients enrolled were collected at the start of treatment, at 12-month follow-up, and at the last follow-up assessment. One hundred seven patients (46 females, 187 eyes) were enrolled, 66 (61.7%) treated with ADA and 41 (38.3%) with IFX. Bilateral involvement was observed in 80 cases. The mean follow-up was 26.45 ± 21.71 months for ADA patients and 56.60 ± 56.04 months for IFX patients. The overall decrease of uveitis frequency during the first 12 months of treatment was 66.7% in the IFX group and 84.2% in the ADA group, compared to the previous 12 months ( p  = 0.09). A significantly higher corticosteroid dosage was found among patients treated with ADA at the last follow-up visit ( p  = 0.008). The percentage of patients co-administered with corticosteroids was significantly higher among ADA patients both at the 12-month visit ( p  = 0.03) and at the last visit ( p  = 0.0004). The frequency of uveitic macular edema (UME) was significantly higher among patients treated with ADA compared to those treated with IFX at the 12-month assessment ( p  = 0.015) and at the last follow-up visit ( p  = 0.011); central macular thickness was significantly higher in ADA group compared to the IFX group at the last follow-up assessment ( p  = 0.04). ADA and IFX have shown a similar efficacy in controlling uveitis relapses, but IFX showed a more pronounced corticosteroid sparing effect and a significantly higher capacity in resolving UME compared to ADA.