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In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent
Magnetic resonance in medicine, 2007-07, Vol.58 (1), p.55-64
Surányi, Pál
Kiss, Pál
Ruzsics, Balazs
Brott, Brigitta C.
Simor, Tamás
Elgavish, Ada
Baker, Robert A.
Saab-Ismail, Nada H.
Elgavish, Gabriel A.
2007
Details
Autor(en) / Beteiligte
Surányi, Pál
Kiss, Pál
Ruzsics, Balazs
Brott, Brigitta C.
Simor, Tamás
Elgavish, Ada
Baker, Robert A.
Saab-Ismail, Nada H.
Elgavish, Gabriel A.
Titel
In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent
Ist Teil von
Magnetic resonance in medicine, 2007-07, Vol.58 (1), p.55-64
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
The phenomenological tissue kinetics of Gd(ABE‐DTTA) was investigated in myocardial infarction (MI). Reperfused infarction was generated by balloon catheter in closed‐chest canines (N = 11). Forty‐eight hours thereafter, inversion‐recovery (IR)‐prepared fast gradient‐echo control images were acquired with varying inversion times (TIs). Precontrast R1 maps were calculated from the TI dependence of signal intensity (SI) using nonlinear curve fitting. Then 0.05 mmol/kg Gd(ABE‐DTTA) was administered I.V. In 11 dogs postcontrast R1 maps were generated at 24 hr and 48 hr postcontrast. In five dogs measurements were also repeated at 108 hr and 12 days. In one dog early measurement was carried out at 4 hr. ΔR1 values for blood and viable and infarcted myocardium were calculated at each time point by subtracting the precontrast R1 from the postcontrast R1. Gd(ABE‐DTTA) showed significant, progressive accumulation into infarcts during the first 2 days (kin = 0.39 hr–1) and a delayed clearance (kout = 0.005 hr–1). Among the time points sampled, the maximum infarct ΔR1 was detected at 48 hr (1.72 s–1). Contrast agent (CA) in infarcted tissue was detectable for 12 days. Clearance from blood and viable myocardium occurred in parallel and was completed by 108 hr. Gd(ABE‐DTTA) displays slow, tissue‐persistent kinetics and partly intravascular, partly extravascular characteristics. It demonstrates high affinity for infarcted myocardium and induces highlighting of infarcts between 4 hr and 12 days following administration. Magn Reson Med 58:55–64, 2007. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.21249
Titel-ID: cdi_proquest_miscellaneous_20857593
Format
–
Schlagworte
Animals
,
contrast agent kinetics
,
Contrast Media - pharmacokinetics
,
Dogs
,
Magnetic Resonance Imaging
,
Male
,
myocardial infarction
,
Myocardial Infarction - metabolism
,
Myocardium - metabolism
,
Organometallic Compounds - pharmacokinetics
,
Pentetic Acid - pharmacokinetics
,
R1-mapping
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