Details

Autor(en) / Beteiligte

• Sisodia, Rashmi
• Ahaskar, Muktika
• Sharma, K V
• Singh, Smita

Titel

Modulation of radiation-induced biochemical changes in cerebrum of Swiss albino mice by Grewia Asiatica

Ist Teil von

• Acta neurobiologiae experimentalis, 2008-01, Vol.68 (1), p.32-38

Ort / Verlag

Poland

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• The present study evaluates the possible radioprotective effect of Grewia asiatica fruit (rich in anthocyanin, carotenes, vitamin C, etc.) pulp extract (GAE) on cerebrum of Swiss albino mice exposed to 5 Gy gamma radiation. For this, healthy mice from an inbred colony were divided into four groups: (1) Control (vehicle treated) (2) GAE treated - mice in this group were orally supplemented with GAE (700 m/kg. b.w./day) once daily for fifteen consecutive days, (3) Vehicle treated irradiated mice, and (4) GAE + Irradiated - Mice in this group received distilled water orally equivalent to GAE (700 m/kg. b.w/day) for fifteen days consecutively. Mice were sacrificed at various intervals viz. 1-30 days. Radiation-induced augmentation in the levels of lipid peroxidation of mice cerebrum was significantly ameliorated by GAE pretreatment. Radiation-induced depletion in the level of glutathione and protein was prevented significantly by GAE administration.