Details

Autor(en) / Beteiligte

• Rodríguez-Trujillo, Adriano
• Martí, Cristina
• Angeles, Martina Aida
• Sierra, Adriana
• Esteve, Roser
• Saco, Adela
• Barnadas, Esther
• Marimón, Lorena
• Nicolás, Inmaculada
• Torné, Aureli
• Ordi, Jaume
• del Pino, Marta

Titel

Value of HPV 16/18 Genotyping and p16/Ki-67 Dual Staining to Predict Progression to HSIL/CIN2+ in Negative Cytologies From a Colposcopy Referral Population

Ist Teil von

• American journal of clinical pathology, 2018-10, Vol.150 (5), p.432-440

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2018

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Objectives To assess the prognostic value of human papillomavirus (HPV) 16/18 genotyping and p16/Ki-67 dual staining cytology in high-risk HPV (hrHPV)–positive women with no lesion or minor abnormalities. Methods We evaluated progression to high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grades 2 to 3 or cervical cancer (HSIL/CIN2+), persistence/regression of hrHPV infection in women referred to colposcopy showing hrHPV infection, histology diagnosis different from HSIL/CIN2+, and negative cytology. HPV 16/18 genotyping and dual staining were performed in liquid-based cytologic specimens obtained on the first visit. Results Progression was observed in 16 (8.0%) of 200 women. Those with HPV 16/18 infection had an increased risk of progression compared with women infected by other hrHPV types, and they also showed more persistence. However, no association was observed between progression or persistence and the result of the dual staining. Conclusions HPV 16/18–positive women with no lesions or minor abnormalities are at high risk of progression to HSIL/CIN2+ and hrHPV persistence.