Details

Autor(en) / Beteiligte

• Tanaka, Kazumasa Z
• He, Hongshen
• Tomar, Anupratap
• Niisato, Kazue
• Huang, Arthur J Y
• McHugh, Thomas J

Titel

The hippocampal engram maps experience but not place

Ist Teil von

• Science (American Association for the Advancement of Science), 2018-07, Vol.361 (6400), p.392-397

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2018

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Episodic memories are encoded by a sparse population of hippocampal neurons. In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We found that during memory encoding, only a fraction of CA1 place cells function as engram neurons, distinguished by firing repetitive bursts paced at the theta frequency. During memory recall, these neurons remained highly context specific, yet demonstrated preferential remapping of their place fields. These data demonstrate a dissociation of precise spatial coding and contextual indexing by distinct hippocampal ensembles and suggest that the hippocampal engram serves as an index of memory content.