Details

Autor(en) / Beteiligte

• He, Wanghong
• You, Minli
• Wan, Wanting
• Xu, Feng
• Li, Fei
• Li, Ang

Titel

Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives

Ist Teil von

• Trends in biotechnology (Regular ed.), 2018-11, Vol.36 (11), p.1127-1144

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Periodontitis has become one of the most universal chronic inflammatory diseases worldwide. Subclinical symptom progression, ultimately leading to permanent damage, calls for early diagnosis and long-term monitoring. However, traditional clinical diagnostic methods are complex and expensive, and cannot meet these requirements. Recently, with more biomarkers and the development of new technologies, various point-of-care testing (POCT) platforms have been developed for periodontitis diagnosis and monitoring. These are easy to perform, rapid, low-cost, and are perfectly suited for high-frequency diagnosis of periodontitis at the point-of-care (POC). We summarize existing biomarkers of different periodontitis stages and recent developed POCT platforms (including lab-on-a-chip, paper-based platforms, and chairside tests), discuss their existing challenges and future potential, and provide some inspiration and guidelines for future POC periodontitis testing. Periodontitis has wide prevalence and distribution, and is associated with the progression of several systemic diseases (e.g., diabetes, atherosclerosis, cancers, and Alzheimer's disease). Preventing and treating periodontitis is beneficial to oral and general health, and diagnosis and surveillance of periodontitis are especially important. Existing clinical diagnostic methods for periodontitis can reflect its severity and previous periodontal destruction, but they fail to reflect its present state or allow monitoring and predict its progress. By contrast, periodontitis-related biomarkers can indicate current disease conditions and evaluate treatment effects and future risk. POCT can detect periodontitis biomarkers onsite within 20minutes. Its low cost, ease of use, and speed can help people to pay closer attention to their oral health and decrease the need for dental procedures.