Details

Autor(en) / Beteiligte

• Gu, R X
• Wei, H
• Wang, Y
• Liu, B C
• Zhou, C L
• Lin, D
• Liu, K Q
• Wei, S N
• Gong, B F
• Zhang, G J
• Liu, Y T
• Zhao, X L
• Gong, X Y
• Li, Y
• Qiu, S W
• Mi, Y C
• Wang, J X

Titel

Impact of duration of antibiotic therapy on the prognosis of patients with acute myeloid leukemia who had Gram-negative bloodstream infection in consolidation chemotherapy

Ist Teil von

• Zhōnghuá xuèyèxué zázhì, 2018-06, Vol.39 (6), p.471

Ort / Verlag

China

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To investigate the influence of duration of antibiotic therapy on the prognosis of patients with AML who had Gram-negative bloodstream infection during consolidation chemotherapy. Data were collected retrospectively from 591 patients enrolled from the registered "A Phase III study on optimizing treatment based on risk stratification for acute myeloid leukemia, ChiCTR-TRC-10001202" treatment protocol between September 2010 and January 2016 in different treatment cycles. A total of 119 episodes of Gram-negative bloodstream infection occurred during consolidation chemotherapy. Excluding the 5 episodes in which fever lasted longer than 7 days, 114 episodes of infection were analyzed. The median neutrophil count was 0 (0-5.62)×10(9)/L, median neutropenia duration was 9 (3-26) days, median interval of antibiotics administration was 7 (4-14) days. Logistic regression analysis showed that there is no significant difference on 3-day recurrent fever rate and reinfection by the same type bacteria between antibiotics adm