Details

Autor(en) / Beteiligte

• Brenner, A.V.
• Butler, M.A.
• Wang, S.S.
• Ruder, A.M.
• Rothman, N.
• Schulte, P.A.
• Chanock, S.J.
• Fine, H.A.
• Linet, M.S.
• Inskip, P.D.

Titel

Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

Ist Teil von

• Carcinogenesis (New York), 2007-12, Vol.28 (12), p.2543-2547

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, −1098T>G) and IL6 (rs1800795, −174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.