Details

Autor(en) / Beteiligte

• Nefti, W.
• Darcel, N.
• Fromentin, G.
• Tomé, D.

Titel

Long-term exposure to high-protein diet or high-fat diet have opposite effects on vagal afferent sensitivity to luminal macronutrients, ip cholecystokinin and serotonin

Ist Teil von

• Appetite, 2007-07, Vol.49 (1), p.316-316

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2007

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Long-term exposure to high-fat (HF), high-protein (HP) or high-carbohydrates (HC) diets may lead to alterations of short-term control of food intake, especially through their effects on peripheral sensitivity to macronutrients and gut hormones such as cholecystokinin. Mice were submitted to either HF, HP or HC diet for 2 weeks. Neuronal activation was measured within the first central relay of vagal ascending fibers, the Nucleus of the Tractus Solitarius (NTS) in response to either intragastric gavage of calibrated diet load or peripheral injections of increasing doses of CCK and serotonin. NTS activation was measured using immunohistochemical quantification of c-fos expression performed on brainstem slices. We observed that HP-induced NTS activation of HP-adapted animals was greater than HF-induced NTS activation of HF-adapted animals. This result was consistent with a marked decrease in CCK sensitivity in HF-adapted mice when compared to HP adapted mice. Interestingly dietary condition had no significant effects on serotonin sensitivity. This study suggests that adaptation to HP diet increases sensitivity whereas HF diet decreases sensitivity to gut anorectic signals.