Details

Autor(en) / Beteiligte

• Ait-Azzouzene, Djemel
• Skog, Patrick
• Retter, Marc
• Kouskoff, Valerie
• Hertz, Marc
• Lang, Julie
• Kench, Jennifer
• Chumley, Michael
• Melamed, Doron
• Sudaria, Janice
• Gavin, Amanda
• Martensson, Annica
• Verkoczy, Laurent
• Duong, Bao
• Vela, Jose
• Nemazee, David

Titel

Tolerance-induced receptor selection

Ist Teil von

• Immunological reviews, 2004-02, Vol.197, p.219-230

Erscheinungsjahr

2004

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Receptor editing is a mode of immunological tolerance of B lymphocytes that involves antigen-induced B-cell receptor signaling and consequent secondary immunoglobulin light chain gene recombination. This ongoing rearrangement often changes B-cell specificity for antigen, rendering the cell non-autoreactive and sparing it from deletion. We currently believe that tolerance-induced editing is limited to early stages in B-cell development and that it is a major mechanism of tolerance, with a low-affinity threshold and the potential to take place in virtually every developing B cell. The present review highlights the contributions from our laboratory over several years to elucidate these features.