Details

Autor(en) / Beteiligte

• Beckmann, Sonja
• Denhaerynck, Kris
• Stampf, Susanne
• Saigi‐Morgui, Nuria
• Binet, Isabelle
• Koller, Michael
• Boely, Elsa
• De Geest, Sabina
• Helmy, Remon
• Leppla, Lynn
• Luta, Xhyljeta
• Mauthner, Oliver
• Struker, Marian
• Boehler, Annette
• Gerull, Sabine
• Berben, Lut
• Huynh‐Do, Uyen
• Catana, Emmanuelle
• Seiler, Annina
• Klaghofer, Richard
• Künzler‐Heule, Patrizia
• Burkhalter, Hanna
• Achermann, Rita
• Amico, Patrizia
• Aubert, John‐David
• Banz, Vanessa
• Beldi, Guido
• Benden, Christian
• Berger, Christoph
• Bochud, Pierre‐Yves
• Bucher, Heiner
• Carell, Thierry
• Chalandon, Yves
• Rougemont, Olivier
• Dickenmann, Michael
• Duchosal, Michel
• Elkrief, Laure
• Fehr, Thomas
• Ferrari‐Lacraz, Sylvie
• Garzoni, Christian
• Soccal, Paola Gasche
• Gaudet, Christophe
• Giostra, Emiliano
• Golshayan, Déla
• Hadaya, Karine
• Halter, Jörg
• Heim, Dominik
• Hess, Christoph
• Hillinger, Sven
• Hirsch, Hans H.
• Hofbauer, Günther
• Immer, Franz
• Laesser, Bettina
• Lehmann, Roger
• Lovis, Christian
• Majno, Pietro
• Manuel, Oriol
• Marti, Hans‐Peter
• Martin, Pierre Yves
• Meylan, Pascal
• Mohacsi, Paul
• Morel, Philippe
• Mueller, Ulrike
• Mueller, Nicolas J.
• Mueller‐McKenna, Helen
• Müller, Antonia
• Müller, Thomas
• Müllhaupt, Beat
• Nadal, David
• Pascual, Manuel
• Passweg, Jakob
• Rick, Juliane
• Roosnek, Eddy
• Rosselet, Anne
• Rothlin, Silvia
• Ruschitzka, Frank
• Schanz, Urs
• Schaub, Stefan
• Schnyder, Aurelia
• Seiler, Christian
• Steiger, Jürg
• Stirnimann, Guido
• Toso, Christian
• Van Delden, Christian
• Venetz, Jean‐Pierre
• Villard, Jean
• Wick, Madeleine
• Wilhelm, Markus
• Yerly, Patrick

Titel

New‐onset obesity after liver transplantation—outcomes and risk factors: the Swiss Transplant Cohort Study

Ist Teil von

• Transplant international, 2018-11, Vol.31 (11), p.1254-1267

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Weight gain after liver transplantation (LTx) facilitates development of new‐onset obesity; however, its risk factors and outcomes are poorly understood. We identified the impact of new‐onset obesity on cardiovascular events (CVEs) and patient survival, and risk factors for new‐onset obesity. Multiple Cox regression models examined risk factors for CVEs, patient survival, and new‐onset obesity in 253 adults (mean age 52.2 ± 11.6 years, male gender 63.6%, mean follow up 5.7 ± 2.1 years). Cumulative incidence of post‐LTx CVE was 28.1%; that of new‐onset obesity was 21.3%. Regardless of CVE at LTx, post‐LTx CVEs were predicted by new‐onset obesity [Hazard Ratio (HR), 2.95; P = 0.002] and higher age at LTx (HR, 1.05; P < 0.001). In patients without known pre‐LTx CVEs (n = 214), risk factors for post‐LTx CVEs were new‐onset obesity (HR, 2.59; P = 0.014) and higher age (HR, 1.04; P = 0.001). Survival was not associated with new‐onset obesity (P = 0.696). Alcoholic liver disease predicted new‐onset obesity (HR, 3.37; P = 0.025), female gender was protective (HR, 0.39; P = 0.034). In 114 patients with available genetic data, alcoholic liver disease (HR, 12.82; P = 0.014) and hepatocellular carcinoma (HR, 10.02; P = 0.048) predicted new‐onset obesity, and genetics remained borderline significant (HR, 1.07; P = 0.071). Early introduction of post‐LTx weight management programs may suggest a potential pathway to reduce CVE risk.