Details

Autor(en) / Beteiligte

• Zou, Linhua
• Barnett, Brian
• Safah, Hana
• Larussa, Vincent F
• Evdemon-Hogan, Melina
• Mottram, Peter
• Wei, Shuang
• David, Odile
• Curiel, Tyler J
• Zou, Weiping

Titel

Bone Marrow Is a Reservoir for CD4 super(+)CD25 super(+) Regulatory T Cells that Traffic through CXCL12/CXCR4 Signals

Ist Teil von

• Cancer research (Chicago, Ill.), 2004-11, Vol.64 (22), p.8451-8455

Erscheinungsjahr

2004

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• CD4 super(+)CD25 super(+) regulatory T cells (Tregs) mediate peripheral T-cell homeostasis and contribute to self-tolerance. Their homeostatic and pathologic trafficking is poorly understood. Under homeostatic conditions, we show a relatively high prevalence of functional Tregs in human bone marrow. Bone marrow strongly expresses functional stromal-derived factor (CXCL12), the ligand for CXCR4. Human Tregs traffic to and are retained in bone marrow through CXCR4/CXCL12 signals as shown in chimeric nonobese diabetic/severe combined immunodeficient mice. Granulocyte colony-stimulating factor (G-CSF) reduces human bone marrow CXCL12 expression in vivo, associated with mobilization of marrow Tregs to peripheral blood in human volunteers. These findings show a mechanism for homeostatic Treg trafficking and indicate that bone marrow is a significant reservoir for Tregs. These data also suggest a novel mechanism explaining reduced acute graft-versus-host disease and improvement in autoimmune diseases following G-CSF treatment.