Details

Autor(en) / Beteiligte

• Greco, D.
• Kocyigit, D.
• Adorni, M.P.
• Marchi, C.
• Ronda, N.
• Bernini, F.
• Gurses, K.M.
• Canpinar, H.
• Guc, D.
• Oguz, S.H.
• Gurlek, A.
• Strazzella, A.
• Simonelli, S.
• Tokgozoglu, L.
• Zimetti, F.

Titel

Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women

Ist Teil von

• Nutrition, metabolism, and cardiovascular diseases, 2018-08, Vol.28 (8), p.822-829

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Low vitamin D (vitD) has been linked to increased cardiovascular (CV) risk, but the effects of vitD supplementation are not clarified. We evaluated the impact of vitD normalization on HDL cholesterol efflux capacity (CEC), which inversely correlates with CV risk, the proatherogenic serum cholesterol loading capacity (CLC), adipokine profile and subclinical atherosclerosis. Healthy premenopausal women with vitD deficiency (n = 31) underwent supplementation. Subclinical atherosclerosis was evaluated by flow-mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AIx), measured with standard techniques. HDL CEC and serum CLC were measured by a radioisotopic and fluorimetric assay, respectively. Malondialdehyde (MDA) in HDL was quantified by the TBARS assay. Pre-β HDL was assessed by 2D-electrophoresis. Serum adipokines were measured by ELISA. VitD replacement restored normal levels of serum 25-hydroxyvitamin D (25OHD) and significantly improved FMD (+4%; p < 0.001), PWV (−4.1%: p < 0.001) and AIx (−16.1%; p < 0.001). Total CEC was significantly improved (+19.5%; p = 0.003), with a specific increase in the ABCA1-mediated CEC (+70.8%; p < 0.001). HDL-MDA slightly but significantly decreased (−9.6%; p = 0.027), while no difference was detected in pre-β HDL. No change was observed in aqueous diffusion nor in the ABCG1-mediated CEC. Serum CLC was significantly reduced (−13.3%; p = 0.026). Levels of adiponectin were increased (+50.6%; p < 0.0001) and resistin levels were decreased (−24.3%; p < 0.0001). After vitD replacement, an inverse relationship was found linking the ABCA1-mediated CEC with pre-β HDL (r2 = 0.346; p < 0.001) and resistin (r2 = 0.220; p = 0.009). Our data support vitD supplementation for CV risk prevention. •N = 31 healthy young women with vitamin D (vitD) deficiency underwent vitD replacement.•VitD improved total and ABCA1-mediated HDL cholesterol efflux capacity.•VitD reduced serum cholesterol loading capacity.•VitD replacement ameliorated adipokine profile and subclinical atherosclerosis.•Our data support vitD replacement for prevention of cardiovascular diseases.