Details

Autor(en) / Beteiligte

• Chin, Chih-Liang
• Pai, Madhavi
• Bousquet, Peter F
• Schwartz, Annette J
• O'Connor, Elizabeth M
• Nelson, Christine M
• Hradil, Vincent P
• Cox, Bryan F
• McRae, Bradford L
• Fox, Gerard B

Titel

Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways

Ist Teil von

• Journal of neuroimmunology, 2009-06, Vol.211 (1), p.49-55

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract USPIO-enhanced MRI allows non-invasive visualization of mononuclear cell infiltration into CNS lesions in MS and EAE. Herein, we show a distinct spatiotemporal pattern of CNS lesions that reveals the involvement of spino-olivocerebellar pathways in MOG-induced EAE rats using USPIO-enhanced MRI. Specifically, lesions of the inferior olives were observed primarily in the acute phase whereas lesions of cerebellum or spinal cord/brainstem were observed during the relapse phase. Further, behavioral deficits observed from these animals are consistent with the functional role of spino-olivocerebellar pathways in coordination and movement. Collectively, our results provide new insights into the pathophysiology of this animal model of MS.