Chemical and Pharmaceutical Bulletin, 2009/03/01, Vol.57(3), pp.294-297
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Structure of New Monoterpene Glycoside from Sibiraea angustata RCHD. and Its Anti-obestic Effect
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 2009/03/01, Vol.57(3), pp.294-297
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A new monoterpene glycoside (1) isolated from the aerial part of Sibirae angustata RCHD. (Rosaceae) was found to be 1-O-β-D-glucopyranosyl-geraniol-5,10-olide and named as sibiskoside. Acute toxicity study revealed that oral administration of 1 (2.5 g/kg body weight) to mice resulted in no death and no evidence of abnormalities in internal organs. Its oral administration to the mice reared with high-fat diet resulted in weight-loss, which was also reflected in serum triglyceride and sugar level, and the weight of abdominal fat. Sibiskoside could be considered to be an active ingredient of Liucha for exerting weight-loss effect in a drink of S. angustata.
- Sprache
- Englisch; Japanisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.57.294Titel-ID: cdi_proquest_miscellaneous_20616987
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Anti-Obesity Agents - chemistry, Anti-Obesity Agents - pharmacology, Anti-Obesity Agents - toxicity, Glycosides - chemistry, Glycosides - isolation & purification, Glycosides - pharmacology, Glycosides - toxicity, Mice, monoterpene, Monoterpenes - chemistry, Monoterpenes - isolation & purification, Monoterpenes - pharmacology, Monoterpenes - toxicity, obesity-prevention, Plant Extracts - chemistry, Rosaceae, Rosaceae - chemistry, serum triglyceride level, Sibiraea angustata, sibiskoside