Details

Autor(en) / Beteiligte

• Steele, MacGregor
• Hitzler, Johann
• Doyle, John J.
• Germeshausen, Manuela
• Fernandez, Conrad V.
• Yuille, Kim
• Dror, Yigal

Titel

Reduced intensity hematopoietic stem-cell transplantation across human leukocyte antigen barriers in a patient with congenital amegakaryocytic thrombocytopenia and monosomy 7

Ist Teil von

• Pediatric Blood & Cancer, 2005-08, Vol.45 (2), p.212-216

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited bone marrow failure syndrome that has the potential to progress to pancytopenia and acute myeloid leukemia. Hematopoietic stem‐cell transplantation (HSCT) is presently the only curative treatment approach. We used a reduced intensity transplantation regimen in a CAMT patient with aplastic anemia and monosomy 7 who had no matched related donor. The patient had rapid and durable engraftment with minimal complications and is well 24 months post‐transplantation. Thus, reduced intensity conditioning might be a feasible approach to stem‐cell transplantation in patients with CAMT who do not have a related donor and who are at increased risk of toxicity from standard conditioning regimens. © 2005 Wiley‐Liss, Inc.