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Clinical presentations of neuromyelitis optica spectrum disorders with ultra-longitudinally extensive transverse myelitis
Ist Teil von
Zhong hua yi xue za zhi, 2018-06, Vol.98 (21), p.1658-1663
Ort / Verlag
China
Erscheinungsjahr
2018
Quelle
MEDLINE
Beschreibungen/Notizen
To analyze the clinical presentations of neuromyelitis optica spectrum disorders (NMOSD) with ultra-longitudinally extensive transverse myelitis (uLETM), in order to improve the diagnostic accuracy of this disorder.
Twenty-two uLETM patients was recruited and retrospectively analyzed for general clinical characteristics, laboratory tests and MRI characteristics, as well as therapeutic.
(1)The Male-to-female ratio was 1∶6. The median onset age was 31 years old. The duration from the first relapse to the onset was 5.5 months. (2)The positive rate of serum water channel aquaporin-4 antibody (AQP4-Ab) in the acute phase was 86.4%. The positive rate of cerebrospinal fluid (CSF) AQP4-Ab in the acute phase was 69.2%. The positive rate of autoimmune antibodies was 72.7%. There was a remarkable difference (
=-12.632,
=0.000) in serum AQP4-Ab titer levels between with the acute and remission period (median titer of 1∶244.78 to 1∶139.63). There was a remarkable difference (
=-20.161,
=0.000) in geometric mean of serum A